Web(a) A cross-section of a normal human glomerular capillary. Arrows indicate the foot processes with interconnecting ultrathin slit diaphragms. (b) Significant changes in the glomerular filtration barrier in a patient with heavy proteinuria due to a primary glomerulopathy. Web14 apr. 2024 · The APOL1 gene encodes for the protein apolipoprotein L1. Historically, this gene grants innate immunity against most strains of Trypanosoma brucei. Two gain-of-function Apolipoprotein L1 (APOL1) variants G1 or G2 were first determined among individuals of African descent with a high prevalence found in Western Africa [ 8, 9 ].
Human trypanolytic factor APOL1 forms pH-gated cation-selective ...
WebHuman trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers : Relevance to trypanosome lysis. / Thomson, Russell; Finkelstein, Alan. In: … WebStudy of the mechanism by which T. b. rhodesiense escapes lysis by human serum led to the identification of an ionic-pore-forming apolipoprotein - known as apolipoprotein L1 - … chip halbach
A Brief History of APOL1: A Gene Evolving - ScienceDirect
Web7 mei 2014 · Human-infective T. b. rhodesiense, which causes acute African sleeping sickness, arose from animal-infective T. b. brucei through the evolution of a virulence … Web12 jun. 2024 · The discovery that apolipoprotein L1 (APOL1) is the trypanolytic factor of human serum raised interest about the function of APOLs, especially following the … Web7 mei 2014 · APOL1 is the main trypanolytic component of human trypanosome lytic factor (TLF). TLF consists of two HDL subfractions (TLF1 and TLF2) that contain … chip haines dentist